1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors.
نویسندگان
چکیده
High-throughput screening of the P&GP corporate repository against several protein tyrosine phosphatases identified the sulfamic acid moiety as potential phosphotyrosine mimetic. Incorporation of the sulfamic acid onto a 1,2,3,4-tetrahydroisoquinoline scaffold provided a promising starting point for PTP1B inhibitor design.
منابع مشابه
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عنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 16 6 شماره
صفحات -
تاریخ انتشار 2006